Power Hydra Flow: deep hydration starts beneath the skin
6 min. read
BIOLOGYST · Cellular Beauty & Glow
Power Hydra Flow: Deep Hydration Starts Under the Skin
Collagen, hyaluronic acid, elastin: understanding and acting from within.
Your skin feels tight, lacks suppleness, your facial contours sag, and wrinkles deepen. You apply cream after cream, but the effects remain superficial, temporary, never truly lasting. This is normal. Because true hydration, true firmness, and true elasticity are not built on the surface. They are built in the dermis, 1 to 2 mm under the skin, where no cream can penetrate.
This is the path that dermo-nutritional research explores: that of active ingredients taken orally, studied for their fate in the extracellular matrix of the dermis. It is based on this approach that Power Hydra Flow was formulated. Here is what the published works describe, and what they do not say.
The sponge and trellis analogy. Imagine the dermis as a three-dimensional sponge whose walls are made of intertwined threads (collagen and elastin). The sponge is soaked in a thick gel (hyaluronic acid) that retains water. When the threads thin and become sparse (collagen loss), when the gel dries out (hyaluronic acid loss), the sponge shrivels: the skin sags, wrinkles, and loses its bounce. Applying a moisturizing cream to a dried-out sponge only dampens the surface; the inside remains dry.
Why your skin dehydrates: even if you drink water
Water in the skin: a matter of structure, not quantity
It is often believed that dry skin is a matter of the amount of water drunk. This is a simplistic view. The skin retains water thanks to a network of specialized molecules: notably hyaluronic acid, proteoglycans, and glycosaminoglycans, which capture water molecules and hold them in the tissues. If these molecules are lacking or degrade, water leaves the skin even if you drink enough.
Skin consists of two main layers:
What is lost over time, and faster than you think
From the age of 25, collagen production decreases by about 1% per year. By 40, skin has lost an average of 15% of its collagen stores. By 50, the drop in hyaluronic acid production accelerates further, exacerbated by the decline in estrogen during menopause.
These losses are accelerated by sun exposure (UV rays degrade collagen via matrix metalloproteinases), smoking, pollution, excessive sugar (which creates glycation bridges that stiffen collagen fibers), and chronic stress.
What is observed when connective tissue depletes with age
The 3 pillars of the dermis: collagen, elastin, hyaluronic acid
Collagen: the reinforced concrete of your skin
Collagen accounts for 75% of dermal proteins. These are long protein fibers braided into triple helices that give the skin its mechanical resistance and volume. Without collagen, the skin sags like a fabric that has lost its weave.
There are several types of collagen in the skin. Types I and III are the most abundant. From the age of 25, fibroblasts (the cells that produce collagen) slow down their production. In parallel, degradation enzymes (metalloproteinases) remain active, creating a progressive imbalance between synthesis and destruction.
Clinical study
Hydrolyzed collagen peptides, skin elasticity, and hydration
Randomized, double-blind clinical trial (n=69 women, 35-55 years old, 8 weeks). Supplementation with hydrolyzed collagen peptides significantly improved skin elasticity (+7% vs placebo), hydration (+28%), and dermal density. The effects were more pronounced in women over 50. The authors observe an increase in fibroblast activity and stimulation of new collagen synthesis.
Elastin: the spring of your skin
Elastin is the protein that allows skin to return to its shape after deformation: like an elastic band. It is present in much smaller quantities than collagen (4% of dermal proteins), but its role is irreplaceable: without it, skin remains creased after being pinched, the oval sags, and features drop.
Unlike collagen, elastin is practically impossible to reproduce after adulthood. The elastin stock is mainly built up during childhood and adolescence. What is lost – due to sun, smoking, or time – does not spontaneously regenerate. This explains the research interest in nutritional contributions for connective tissue, and in lifestyle factors that accelerate its degradation.
Clinical study
Natural eggshell membrane (NEM/OVOMET®): skin flexibility and joint comfort
Randomized, double-blind clinical trial (n=67, 30 days) evaluating natural eggshell membrane (NEM/OVOMET®), a concentrated source of collagen, elastin, and glycosaminoglycans. Compared to placebo, the supplemented group showed significant improvement in skin flexibility and hydration, as well as a reduction in joint pain and stiffness. The authors conclude that the eggshell membrane protein matrix provides a complete structural contribution to connective tissues.
Hyaluronic acid: the dermis's water sponge
Hyaluronic acid (HA) is a glycosaminoglycan naturally present in the dermis. Its main property is remarkable: a single molecule can capture and retain up to 1,000 times its weight in water. It is what gives the dermis its plump, bouncy, smooth appearance, the famous "baby skin."
The HA stock decreases with age: at 50, we have half as much as at 20. At 60, the reduction can reach 75%. This decline is accelerated by UV rays, which fragment HA molecules via free radicals, and by hyaluronidase enzymes, which degrade it faster than it is synthesized.
Clinical study
Oral hyaluronic acid 120 mg/day: skin hydration, dryness, and roughness
Randomized, double-blind, placebo-controlled trial (n=96, 12 weeks). Oral hyaluronic acid supplementation (120 mg/day) significantly improved skin hydration, reduced dryness and roughness, and increased facial skin suppleness. Histological analyses confirmed an increase in hyaluronic acid content in the superficial layers of the epidermis, showing that oral HA effectively reaches the skin.
Skin and joints: the same connective tissue
Articular cartilage and skin share the same basic architecture: an extracellular matrix rich in collagen, elastin, and glycosaminoglycans. It is no coincidence that people whose skin ages quickly often also experience early joint pain: both phenomena are two sides of the same biological reality: the depletion of connective tissue.
The synovial fluid that lubricates the joints is also rich in hyaluronic acid. Its decrease with age results in less well-lubricated joints, friction, morning stiffness, and pain during effort. Oral intake of collagen, elastin, and HA is studied for its simultaneous action on the skin and joints.
Clinical study
Dual action of oral hyaluronic acid: skin and knee
Clinical study on 60 adult subjects (12 weeks): oral hyaluronic acid intake led to significant improvement in skin hydration and elasticity, as well as a reduction in knee pain in subjects with joint discomfort. This study illustrates the dual action of oral HA: cutaneous AND articular: via its systemic redistribution.
Clinical study
Eggshell membrane (NEM/OVOMET®): joint mobility and stiffness at 4 weeks
Clinical study on eggshell membrane supplementation (NEM/OVOMET®) in subjects suffering from joint discomfort. After 4 weeks, a significant reduction in joint pain and stiffness was observed, with improved functional mobility. The authors attribute these results to the combined contribution of type I, V, and X collagen, elastin, chondroitin sulfate, and hyaluronic acid contained in the eggshell membrane.
“What you do for your skin, you also do for your joints. Both speak the same language: that of connective tissue.”
Power Hydra Flow: the complete formula
Power Hydra Flow is BIOLOGYST's dermo-nutritional stick. It combines four active ingredients with complementary mechanisms, at dosages aligned with those used in the studies cited below. The patented forms used are detailed in our active ingredients dossier.
OVODERM® / OVOMET® · 300 mg: standardized natural eggshell membrane
Complete supply of extracellular matrix proteins. OVODERM® and OVOMET® are standardized eggshell membrane extracts: a thin film naturally rich in type I, V, and X collagen, elastin, chondroitin sulfate, and hyaluronic acid. It is the only food source that concentrates these four extracellular matrix components in a single ingredient. After absorption, these peptides stimulate fibroblasts to synthesize new collagen and contribute to the elastic network of the dermis. They act simultaneously on the skin and articular cartilage.
Clinical study
Natural eggshell membrane (NEM®): pain and stiffness from 10 days
Significant reduction in joint pain (−26%) and stiffness (−28%) from 10 days of supplementation, with improvement in functional mobility and skin suppleness at 30 days. Natural eggshell membrane is the only source that simultaneously provides collagen, elastin, chondroitin, and HA in a single active ingredient.
ExceptionHYAL® Star Hyaluronic Acid · 100 mg: high bioavailability form
Deep hydration and water retention in the dermis. ExceptionHYAL® Star is a form of hyaluronic acid with optimized molecular weight for oral bioavailability. Unlike high molecular weight forms, which are poorly absorbed, this formula is fragmented to pass through the intestinal barrier and reach the dermis via the bloodstream. Once in the skin tissue, it binds to CD44 receptors on fibroblasts, stimulates endogenous hyaluronic acid production, and replenishes intradermal water reserves. Its dual action – direct supply and synthesis stimulation – makes it one of the most complete oral HA forms available.
Clinical study
Oral HA 120 mg/day for 12 weeks: hydration and elasticity
Oral HA supplementation (120 mg/day, 12 weeks, n=96): significant improvement in hydration (+22%), elasticity, and skin suppleness. Histological analyses confirm an increase in HA content in the epidermis. Subjects reported a reduction in the sensation of tight skin and an improvement in radiance as early as week 4.
Vitamin C · 200 mg: 250% NRV
Essential cofactor for collagen synthesis. Vitamin C contributes to normal collagen formation for the normal function of the skin. It is the irreplaceable enzymatic cofactor for prolyl and lysyl hydroxylases: the two enzymes that produce collagen. Without vitamin C, these enzymes are inactive: the collagen produced is poorly structured, unstable, and degrades prematurely. At 200 mg per serving, Power Hydra Flow's vitamin C supports the action of OVODERM® by ensuring that each absorbed collagen peptide can be transformed into a strong collagen fiber. It also contributes to the protection of cells from oxidative stress and regenerates vitamin E.
Clinical study
Vitamin C and Skin Health: systematic review
This systematic review on vitamin C and skin confirms that vitamin C is essential for the synthesis and stabilization of dermal collagen. The skin concentrates vitamin C up to 10 times more than blood plasma, demonstrating its critical role in this organ. Even moderate vitamin C deficiency significantly reduces collagen production and accelerates extracellular matrix degradation.
Dry Aloe vera extract · 10 mg
Fibroblast stimulation and hydration support. Aloe vera contains mucopolysaccharides (including acemannan) that stimulate dermal fibroblasts to produce collagen and hyaluronic acid. In the formula, it is combined with HA and collagen peptides, on which it acts upstream, at the cellular level. Clinical studies have observed that oral supplementation with Aloe vera gel improves skin elasticity and reduces superficial wrinkles by increasing dermal collagen density.
Clinical study
Oral Aloe vera gel: skin elasticity and collagen density
Randomized controlled trial (n=30 women, 45 years and older, 90 days): oral Aloe vera gel supplementation significantly improved skin elasticity and reduced facial wrinkle depth, with a measurable increase in collagen production and extracellular matrix density through histological analysis. The authors confirm that oral Aloe vera directly stimulates cutaneous fibroblasts.
How to take Power Hydra Flow?
1 stick per day, preferably in the morning, dissolved in a large glass of water. Recommended course of 2 to 3 months: effects on skin hydration are noticeable from 4 to 6 weeks, those on elasticity and volume from 2 months. Collagen takes time to renew: it is important not to stop too early.
Power Hydra Flow is particularly aimed at skin lacking firmness and elasticity, people who wish to support their skin quality over time, dry skin resistant to topical treatments, and anyone experiencing mild joint discomfort associated with aging skin. Not recommended for pregnant or breastfeeding women.
“Deep hydration is not applied. It is drunk.”
Summary
Firm, hydrated, and plump skin is not built on the surface. It is built in the dermis: where creams cannot reach. To act deeply, it is necessary to nourish fibroblasts, replenish hyaluronic acid stores, and support collagen and elastin synthesis orally.
Power Hydra Flow combines in a single stick: OVODERM®/OVOMET® for matrix proteins, ExceptionHYAL® Star for deep hydration, vitamin C for collagen synthesis, and Aloe vera for fibroblast stimulation. All documented by double-blind clinical studies.
Two to three months of treatment: this is the time required for connective tissue renewal.
Frequently Asked Questions
Is a moisturizing cream enough to deeply hydrate the skin?
No: a cream acts on the epidermis, the superficial layer, by delaying water evaporation. Structural hydration occurs in the dermis, 1 to 2 mm below the surface, where the extracellular matrix of collagen, elastin, and hyaluronic acid is located, which topical treatments do not reach.
At what rate do we lose collagen and hyaluronic acid?
Collagen production decreases by approximately 1% per year from the age of 25: by 40, the skin has lost an average of 15% of its reserves. For hyaluronic acid, we have half as much at 50 as at 20, and the reduction can reach 75% at 60.
Does orally ingested hyaluronic acid really reach the skin?
Yes. In the trial by Kawada et al. (2014, n=96, 12 weeks, 120 mg/day), histological analyses confirmed an increase in hyaluronic acid content in the epidermis. Optimized molecular weight forms, such as ExceptionHYAL® Star, are fragmented to cross the intestinal barrier.
How long does it take to see a change?
Allow 4 to 6 weeks for skin hydration and approximately 2 months for elasticity and volume. The recommended course is 2 to 3 months, with one stick per day, as collagen renewal is a slow process.
Does Power Hydra Flow also work on joints?
Skin and cartilage share the same extracellular matrix, and synovial fluid is rich in hyaluronic acid. Studies on natural egg membrane report a 26% reduction in joint pain and 28% in stiffness within 10 days (Ruff et al., 2009). Other analyses are available in the BIOLOGYST Journal, notably on Antioxidant Defense, which also contains ExceptionHYAL® Star hyaluronic acid, and on Skin Longevity, focused on ceramides.
BIOLOGYST: This article is provided for informational purposes only and does not replace the advice of a healthcare professional. Food supplement is not a substitute for a varied and balanced diet. biologyst.com
Search by theme
Read also
The Essentials
Take our diagnostic and discover your skin type and the routine best suited to your needs.
