Quatrefolic®

6 min. read

30/06/2026

Planche botanique d'épinard — Quatrefolic®, folate actif breveté (vitamine B9), BIOLOGYST

Patented active ingredients · Energy

Quatrefolic®

A patented 4th generation active folate, directly usable by the body

Quatrefolic® is a patented fourth-generation folate, provided as 5-methyltetrahydrofolate (5-MTHF), the biologically active form of vitamin B9. Unlike conventional folic acid, which must undergo several enzymatic transformations before being utilized by the body, Quatrefolic® is immediately available to cells.

Thanks to its patented technology combining 5-MTHF with a glucosamine salt, Quatrefolic® exhibits excellent stability, high bioavailability, and optimized absorption. This active form is particularly beneficial for individuals with a reduced ability to convert folic acid, especially in the presence of certain MTHFR gene variants.

Quatrefolic® is now recognized as one of the most effective forms of vitamin B9 available in supplementation.

Why we chose Quatrefolic®

Patented 4th generation active folate
Directly usable by the body
Excellent stability and bioavailability
Several clinical studies in humans
Suitable for individuals with reduced folic acid conversion

Studied benefits

Optimal support for cellular metabolism

Quatrefolic® directly provides the active form of vitamin B9, essential for cell division mechanisms, DNA synthesis, and tissue renewal.

Better assimilation than conventional folic acid

Studies show that 5-MTHF is more readily available to cells and effectively increases folate status, without requiring prior metabolic transformation.

Energy support

Vitamin B9 helps reduce fatigue and contributes to normal energy metabolism. In combination with other B vitamins, Quatrefolic® supports cellular function and energy production.

Nervous system support

Folates play a role in the normal functioning of the nervous system as well as in the synthesis of certain neurotransmitters involved in cognitive functions and emotional balance.

Contribution to normal homocysteine levels

Quatrefolic® contributes to the normal metabolism of homocysteine, a marker involved in several cardiovascular and metabolic functions.

Scientific evidence

Study	Main results
Lamers et al., 2006	5-MTHF effectively increases circulating folate concentrations and exhibits bioavailability at least equivalent to, if not superior to, folic acid.
Prinz-Langenohl et al., 2009	Improved biological availability of 5-MTHF in adults, with an effective increase in folate status.
Pietrzik et al., 2010	Scientific review confirming the advantages of 5-MTHF as a physiological alternative to conventional folic acid.
Quatrefolic® Scientific Data	Several clinical studies confirm the stability, bioavailability, and effectiveness of Quatrefolic® in improving folate status.

In summary

Directly provides the active form of vitamin B9
Offers better bioavailability than conventional folic acid
Supports energy production and reduces fatigue
Contributes to the normal functioning of the nervous system
Promotes cell renewal and homocysteine metabolism

Level of scientific evidence

★★★★★High

Several clinical trials in humans
Widely documented bioavailability and stability
International benchmark patented ingredient
Scientifically proven efficacy

Where to find Quatrefolic® at BIOLOGYST

Quatrefolic® is present in Energy Daily Flow. Discover all our patented active ingredients.

Frequently Asked Questions

What is Quatrefolic®?

A patented active folate, supplied as 5-MTHF, the directly assimilable form of vitamin B9.

In which BIOLOGYST product can Quatrefolic® be found?

It can be found in Energy Daily Flow.

Is Quatrefolic® scientifically proven?

Yes: folates (vitamin B9) contribute to reducing fatigue and normal psychological function — claims recognized in Europe. In its 5-MTHF form, Quatrefolic® is directly assimilable.