Quatrefolic®

A patented 4th generation active folate, directly usable by the body

Quatrefolic® is a patented fourth-generation folate, provided as 5-methyltetrahydrofolate (5-MTHF), the biologically active form of vitamin B9. Unlike traditional folic acid, which must be converted through several enzymatic steps before being used by the body, Quatrefolic® is immediately available to cells.

Thanks to its patented technology combining 5-MTHF with a glucosamine salt, Quatrefolic® offers excellent stability, high bioavailability, and optimized absorption. This active form is particularly beneficial for individuals with a reduced capacity to convert folic acid, especially in the presence of certain variants of the MTHFR gene.

Quatrefolic® is now recognized as one of the most effective forms of vitamin B9 available in supplementation.

Why we chose Quatrefolic®?

✔ Patented 4th generation active folate

✔ Directly usable by the body

✔ Excellent stability and bioavailability

✔ Several clinical studies in humans

✔ Suitable for individuals with reduced folic acid conversion

Studied benefits

Optimal support for cellular metabolism

Quatrefolic® directly provides the active form of vitamin B9, which is essential for cell division mechanisms, DNA synthesis, and tissue renewal.

Better assimilation than conventional folic acid

Studies show that 5-MTHF is more readily available to cells and effectively increases folate status without requiring prior metabolic conversion.

Energy support

Vitamin B9 helps reduce fatigue and contributes to normal energy metabolism. In combination with other B vitamins, Quatrefolic® supports cellular function and energy production.

Support for the nervous system

Folate is involved in the normal functioning of the nervous system as well as in the synthesis of certain neurotransmitters involved in cognitive functions and emotional balance.

A contribution to normal homocysteine levels

Quatrefolic® contributes to the normal metabolism of homocysteine, a marker involved in several cardiovascular and metabolic functions.

Scientific evidence

In summary

✔ Directly provides the active form of vitamin B9

✔ Offers better bioavailability than conventional folic acid

✔ Supports energy production and reduces fatigue

✔ Contributes to the normal functioning of the nervous system

✔ Promotes cell renewal and homocysteine metabolism

Level of scientific evidence

★★★★★ High

• Several clinical trials in humans

• Widely documented bioavailability and stability

• International reference patented ingredient

• Scientifically proven effectiveness